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Veterinary Manual
Merck and the Merck Veterinary Manual. Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world List Price: $» Buy on Amazon» Buy on Barnes & Noble The Merck Veterinary Manual Eleventh Edition Part 2nd PDF The Merck Veterinary Manual (MVM) Eleventh Edition covers all domesticated species and diseases in veterinary medicine all over the world merck veterinary manual 12th edition pdf free download | سفیر آزما کیان مرجع فروش مواد شمیایی و آزمایشگاهی در ایران برای سفارش با تلفن در تماس باشید. ۰۹۱۲۸۳۰۸۰۹۱ و ۰۹۳۵۷۰۰۷۷۴۳. تلفن های تماس دفتر فروش: و و خانه
Merck veterinary manual 12th edition pdf download
E-mail: COMP-MERGER-REGISTRY ec. Brussels, The terminology of the TFEU will be used throughout this Decision. The omissions are shown thus […]. Where possible the information omitted has been replaced by ranges of figures or a general description. PUBLIC VERSION 2 I. THE PARTIES 3 Merck is a German pharmaceutical and chemical company.
Merck Millipore is organized in three business units: i Bioscience, ii Lab Solutions, and ii Process Solutions. Sigma operates through three business units: i Research, ii Applied, merck veterinary manual 12th edition pdf download, and iii SAFC Commercial custom manufacturing and services.
Sigma will be merged with and into an ad-hoc Merck subsidiary, thus becoming a wholly owned subsidiary of Merck. Outstanding share capital of Sigma will be cancelled at closing in exchange for consideration.
UNION DIMENSION 8 The undertakings concerned have a combined aggregate world-wide turnover of more than EUR 5 million Merck: EUR 10 million, Sigma: EUR 2 million. The notified operation therefore has a Union dimension.
Indeed, the overall positioning of the Parties in the life science business is focused on different areas: while Merck is stronger in raw materials for pharmaceutical production c. EUR […]for Merck versus EUR […]for Sigma in Sigma is focused on bioscience research c. EUR […]for Sigma versus EUR […] for Merck in Laboratory chemicals are chemicals used for research, analytical testing and quality control purposes by a wide range of customers, including academia, laboratories and pharmaceutical companies.
The main role of laboratory chemicals is to allow for a repeated standardized testing with high precision and accuracy according to a predetermined testing protocol. As a result, laboratory chemicals have to meet high quality standards to avoid the presence of any contaminant.
Given the nature of their use, laboratory chemicals are generally sold in catalogue quantities, i, merck veterinary manual 12th edition pdf download. less than 10 kilograms or litres per unit. and the American Chemical Society ACS. As detailed further below, Merck and Sigma are both strong suppliers of laboratory chemicals in the European Economic Area EEA.
Contrary to laboratory chemicals, raw materials used for manufacturing purposes are generally sold in larger volume. In Europe, these standards are laid out in particular by the European Pharmacopoeia Pharm. These biochemicals are used by researchers to understand complex biological systems. As opposed to laboratory chemicals, biochemicals are used in workflow protocols to develop new drugs, diagnostics and therapies, from the initial sample step to the detection step.
Cell culture is a process by which merck veterinary manual 12th edition pdf download are grown under controlled conditions, generally outside of their natural environment. Cell culture products can be used for research purposes, since it is one of the major tools used in cellular and molecular biology to study the physiology and biochemistry of cells and the effects of drugs and toxic compounds on cells.
Cell culture products can also be used as raw materials for the production of biopharmaceuticals. As concerns cell culture for research, Merck is active via its Bioscience division and Sigma via its Research division. Introduction 21 Bioscience products consist of life science reagents and various kits used by researchers to understand complex biological systems and processes in their search for new drugs and therapies.
Therefore, these products are used in a non-regulated discovery-driven environment, with the only requirement to avoid the presence of any substance that could interfere with the biological process being studied. The main customers of bioscience products are i academia and government bodies and ii pharma and biotech. Market definition IV.
molecular and proteomics. However, the Transaction will not lead to affected market in these areas and therefore they would not be further discussed in this Decision. These general biochemicals include among other products dyes and stains and carbohydrates7, merck veterinary manual 12th edition pdf download.
Dyes and stains are products used in different techniques which allow clinical researchers to study various constituent parts of tissue e. nucleus, connecting tissue, etc. by colouring it with a particular colour and making it more visible under microscope magnification. Dyes and stains are not only used for research applications, but can also be used for IVD In-Vitro Diagnostics applications.
IVD tests are performed by clinical laboratory personnel in sampling and observing potentially diseased human tissue which has a direct implication on selecting a treatment for a patient. If used for IVD applications, dyes and stains must undergo the CE marking procedure as they are considered to be medical devices under the relevant EU legislation.
In any event, research and IVD applications correspond to different chemicals that are not substitutable with each other. Carbohydrates are basic components of cellular metabolism, as well as certain proteins receiving post-translational modification such as glycosylation. Each supplier offers a wide range of these products, and is not restricted by material cost or time considerations from switching among them in response to customer demand.
There is no affected market in relation to these products and they will thus not be discussed further in this Decision. case M. This is mainly due to low transport costs, the absence of regulatory barriers and global presence of suppliers, merck veterinary manual 12th edition pdf download. Customers also indicated that their sourcing contracts have EEA or global dimension. Competitive assessment 34 The Transaction gives rise to horizontally affected markets in relation to dyes and stains and carbohydrates, as well as merck veterinary manual 12th edition pdf download bioactive small molecules.
However, as further described below, the increment brought about by the Transaction is generally limited, large competitors will remain active on these markets, and no significant barriers to switching for customers have been identified.
Post-Transaction, there will still remain a large number of competitors active in this market, such as Thermo Fisher and Bio Techne. See also replies to questions 27 and 29 — Phase I questionnaire to customers. Indeed, Sigma is mainly active in dyes and stains for research applications, merck veterinary manual 12th edition pdf download, while Merck is mainly active in dyes and stains for IVD applications. Moreover, there a large number of large competitors active in this market, such as Thermo Fisher, Bio Techne and Enzo, to whom customers can fairly easily turn to post-Transaction.
CELL CULTURE IV. Introduction 41 Cell culture is the process by which cells are grown in controlled conditions, generally outside of their natural environment. Cell culture is one of the main tools used in cellular and molecular biology, since it provides excellent merck veterinary manual 12th edition pdf download systems for studying the physiology and biochemistry of cells and the effects of drugs and toxic compounds on the cells.
It is also used in the development of biological compounds e. vaccines and therapeutic proteins. They are aimed at supplying nutrients to human, animal, insect and plant to stimulate and support the cell growth in vitro i. outside the living organism. For a complete cell culture, additional reagents and supplements are also required. The Transaction does not give rise to an affected market regarding a hypothetical market for IVD dyes and stains.
This is due to the differences in terms of purchasing patterns, pricing and expected quality, merck veterinary manual 12th edition pdf download. Research customers do not require the same level of testing and validation that bio-production customers must undertake in order to comply with various regulations.
As a result of these additional certification requirements bio-production products also tend to be priced at premium compared to research products. Indeed, some suppliers indicated that bio-production customers require higher quality and additional documentation since they are more concerned about the risk of contamination and consistency.
This is mainly due low transport costs, the absence of regulatory barriers and global presence of suppliers. This is mainly due to suppliers being active on an EEA wide or even global basis, products being sold under the same brand names regardless of the different geographic areas and customers concluding contracts at EEA or global level. Specifically, the following affected markets arise as a result of the merck veterinary manual 12th edition pdf download Transaction in this field 19 See replies to question 23 — Phase I questionnaire to customers.
replies to questions 74 and However, as evidenced further below, the Parties have moderate market shares in the downstream markets for the supply of cell culture media for bioproduction. More importantly, regarding hypothetical markets for the supply of raw materials for cell culture media, the Parties supply a variety of raw materials used in different applications including, but not limited to, the production of cell culture mediaand they are not able to distinguish, let alone price discriminate by, the end application of these raw materials.
Moreover, other strong competitors include Lonza and GE, who will continue to exert competitive constraint on the Parties post-Transaction with market shares similar to the one of the merged entity. Finally, cell culture seems to be a segment of life science where a number of specialized niche players are active, which was confirmed during the market investigation. Introduction 61 Raw materials for bio pharmaceutical production include three broad categories of products, namely active pharmaceutical ingredients API and their intermediates; excipients non-active ingredients used in a final drug dosage form ; and biopharm ingredients process chemicals used in biopharmaceutical processes.
Product market 63 Raw materials for bio pharmaceutical production cover a wide range of products used during the manufacturing process of pharmaceuticals, namely API and intermediates, excipients non-active ingredients of a final dosage form, such as binders, fillers, diluents, lubricants, flavours, solvents sweeteners or preservatives, with inter alia lactose, starch, cellulose, magnesium, stearic acid, gelatine, sucrose, talc or sodiumand biopharm ingredients, which cover buffers and stabilizers including inter alia amino acids, carbohydrates and polymers.
The upstream phase consists in the first manufacturing steps including biosynthesis and working cell bank preparation, up to the first purification steps to isolate the pure protein or peptide. The downstream phase includes processes from the chromatography steps to the final formulation of drugs, including e. virus inactivation and nanofiltration.
On the other hand, when used in the downstream or drug formulation phases, raw materials have to adhere to Ph. chemicals that adhere to Pharm. are also called compendial grade products because they are likely to end up in the final drug formulation and thus create safety hazard.
Therefore, even if chemically same or similar, the products used in the upstream and downstream phases are different due to different certification and quality control processes.
Buffers, merck veterinary manual 12th edition pdf download, which may be organic or inorganic, are added to a solution to prevent a rapid change in acidity when acids or bases are added creating a product that has little reaction when it meets other liquids.
Indeed, as indicated above, pharmaceutical companies are legally obliged to use compendial merck veterinary manual 12th edition pdf download buffers when they end up in the final drug formulation. Customers also explained that the situation of regulatory requirements is unclear in relation to buffers.
It could be Ph Eur, other compendia or just relevant parts of these, internal requirements or a combination of these, depending on type of material and use. However, it does not lead to any affected market and, thus, these products will not be further discussed in the Decision.
This illustrates a mutation in the pharmaceutical industry whereby responsibility on the quality and certification of raw materials for production is being shifted to the supplier. The Notifying Party indicates that the main suppliers sell their raw materials for pharmaceutical production on an EEA-wide basis and sometimes global basis, and use the same brand names throughout the EEA.
Furthermore, the Notifying Party submits that there are no regulatory barriers that would prevent the sale of a product throughout the EEA, and that transport costs of such products are very low. See also replies to question 29 — Phase I questionnaire to customers. are defined at EEA-level. Competition assessment 81 As regards biopharm ingredients, and in particular buffers for pharmaceutical production, the Parties have complementary activities.
Merck only supplies compendial buffers mainly inorganic whereas Sigma mostly supplies organic buffers, the great majority of which are non-compendial.
Basic Textbooks \u0026 Study Materials - Veterinary Medicine
, time: 7:43Merck veterinary manual 12th edition pdf download
merck veterinary manual 12th edition pdf free download | سفیر آزما کیان مرجع فروش مواد شمیایی و آزمایشگاهی در ایران برای سفارش با تلفن در تماس باشید. ۰۹۱۲۸۳۰۸۰۹۱ و ۰۹۳۵۷۰۰۷۷۴۳. تلفن های تماس دفتر فروش: و و خانه Merck and the Merck Veterinary Manual. Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world The print edition of the Merck Veterinary Manual is more than 3, pages long. The digital version contains all the content and more. The digital version contains all the content and more. The Merck Veterinary Manual, a key reference guide for veterinary professionals around the world, is now available for free to everyone — the public included — through a mobile blogger.comted Reading Time: 2 mins
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